01857nas a2200385   4500000000100000008004100001260001700042653001500059653001000074653000900084653001200093653001100105653001700116653001000133653001100143653002300154653002800177653001100205653002000216653001200236653000900248653001500257653002500272653000900297653002600306653001600332100001700348700001300365245014300378856004100521300001000562490000700572520087800579022001401457       1974                            d  c1974 Oct-Dec10aAdolescent10aAdult10aAged10aAnimals10aBiopsy10aChick Embryo10aChild10aFemale10aGlycosaminoglycans10aHistological Techniques10aHumans10aHyaluronic Acid10aleprosy10aMale10aMicroscopy10aMycobacterium leprae10aSkin10aStaining and Labeling10aTuberculoma1 aSkinsnes O K1 aMatsuo E00aAcid mucopolysaccharide metabolism in leprosy. 1. Storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy.  uhttp://ila.ilsl.br/pdfs/v42n4a02.pdf  a392-80 v423 a<p>A histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. In contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. The macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tuberculoid in BT cases and the lepromatous expression in BL cases. It is suggested that hyaluronic acid, in a manner similar to M. leprae and lipid, has a quantitatively varied distribution reflecting the immunopathologic spectrum of leprosy. This finding suggests that acid mucopolysaccharide may be significantly involved in that host/parasite interaction in leprosy.</p>  a0148-916X