01163nas a2200277   4500000000100000008004100001260001700042653001100059653002100070653002100091653003300112653003200145653002100177653003200198653002100230653002000251653001200271100001600283700001600299700001900315245007300334300000900407490000700416520044800423022001400871       1977                            d  c1977 Jan-Mar10aHumans10aImmunoglobulin A10aImmunoglobulin D10aImmunoglobulin Fab Fragments10aImmunoglobulin Fc Fragments10aImmunoglobulin G10aImmunoglobulin kappa-Chains10aImmunoglobulin M10aImmunoglobulins10aleprosy1 aKwapinski G1 aKwapinski E1 aDE ALMEIDA J O00aPreliminary investigations on abnormal immunoglobulin(s) in leprosy.  a24-70 v453 a<p>A new, abnormal immunoglobulin designated IgK has been discovered in leprous Rubino-negative sera. The IgK having a negative net charge and its own antigenic specificity appears to be partly related to the Fc fragment of IgA and to Fab fragments of known immunoglobulins, but its net charge is negative at pH 8.8. Its molecule seems to possess kappa but not lambda light polypeptide chains. Implications of this discovery are discussed.</p>  a0148-916X