01344nas a2200241   4500000000100000008004100001260001700042653003300059653003000092653001100122653001200133653001500145653001300160100001300173700001000186700001200196245005300208300001100261490000700272050003200279520077700311022001401088       1985                            d  c1985 Apr-Jun10aDrug Administration Schedule10aDrug Therapy, Combination10aHumans10aleprosy10aProbenecid10aRifampin1 aPankaj R1 aLal S1 aRao R S00aEffect of probenecid on serum rifampicin levels.  a329-330 v57  aInfolep Library - available3 a<p>Serum Rifampicin levels were determined by a microbiological assay using Staphylococcus aureus in 22 cases of leprosy after administering the drug with and without probenecid. Most of the patients showed higher serum rifampicin levels when probenecid was given along with rifampicin. Six patients showed statistically significant increase in the serum levels of the drug when given in the dose of 300 mg along with 1 g of probenecid one hour before breakfast and these levels were comparable with those obtained following administration of 450 mg of rifampicin alone two hours after breakfast. Thus administration of probenecid preceding rifampicin may be employed to reduce cost of drug as well as hepatotoxicity in patients requiring rifampicin for long duration.</p>  a0254-9395