01682nas a2200337   4500000000100000008004100001260001300042653001200055653002500067653001600092653001500108653002000123653001100143653001900154653001000173653001200183653002900195653002700224653003000251653002800281100001200309700001800321700001300339700001500352700001400367245007900381300001100460490001500471520084400486022001401330       2007                            d  c2007 Apr10aAlleles10aCase-Control Studies10aDNA Primers10aHaplotypes10aHLA-DR Antigens10aHumans10aImmunogenetics10aIndia10aleprosy10aMycobacterium Infections10aOligonucleotide Probes10apolymerase chain reaction10aTuberculosis, Pulmonary1 aSingh M1 aBalamurugan A1 aKatoch K1 aSharma S K1 aMehra N K00aImmunogenetics of mycobacterial infections in the North Indian population.  a228-300 v69 Suppl 13 a<p>Several lines of evidence highlight the genetic basis of risk to develop mycobacterial diseases. Human leukocyte antigen (HLA)-DR2 alleles (DRB1*1501 and DRB1*1502) have been found to be strongly associated with mycobacterial disease, especially the more severe forms such as lepromatous leprosy and multidrug-resistant pulmonary tuberculosis. In this study, DNA-based high-resolution typing techniques of polymerase chain reaction-sequence-specific oligonucleotide probe were used to determine the distribution of HLA-DR/DQ alleles in patients with leprosy and pulmonary tuberculosis. Analysis of different DR2 subtypes based on valine/glycine dimorphism at codon beta86 in pocket 1 of HLA-DR showed an inverse relationship of DR2 alleles with V/G as the severity of disease increased both in leprosy and in pulmonary tuberculosis.</p>  a0001-2815