01252nas a2200277   4500000000100000008004100001260001300042653001500055653001000070653002900080653001200109653001100121653001200132653001700144653001300161653000900174653001700183100001600200700001600216245006200232300001100294490000700305050003200312520061600344022001400960       1979                            d  c1979 Oct10aAdolescent10aAdult10aClinical Trials as Topic10aDapsone10aHumans10aleprosy10aNasal Septum10aRifampin10aSkin10aTime Factors1 aGirdhar B K1 aDesikan K V00a'Pulsed' rifampicin therapy in leprosy. A clinical study.  a475-800 v51  aInfolep Library - available3 a<p>A trial of monthly administration of Rifampicin in 2 doses of 900 mg each on successive days for 3 months along with DDS 100 mg daily has been undertaken. The results have been compared with 2 groups of controls, one, which was administered 300 mg Rifampicin daily for 3 months followed by DDS, and the other which received 100 mg DDS alone. The findings show that the efficacy of this pulsed regimen is almost similar to continuous rifampicin administration and better than DDS alone. No significant adverse effects were encountered in the trial. The regimen thus merits large scale trials in the field.</p>  a0024-1024