01640nas a2200313   4500000000100000008004100001260000900042653002200051653002500073653000900098653001100107653002000118653002900138653001200167653003400179653002300213653001400236653002800250653001400278653001300292100001500305700001100320700001400331245005800345300001100403490000700414520089100421022001401312       1985                            d  c198510aAntibodies, Viral10aAntibody Specificity10aGels10aHumans10aImmunodiffusion10aInfectious Mononucleosis10aleprosy10aLupus Erythematosus, Systemic10aMultiple Sclerosis10aNeoplasms10aNewcastle disease virus10aSepharose10aSyphilis1 aPowell J A1 aKano K1 aMilgrom F00aSpecificity of antibodies to Newcastle disease virus.  a336-400 v763 a<p>Specificity of antibodies to Victoria strain of Newcastle disease virus (NDV) found in infectious mononucleosis (IM) and other pathologic sera was investigated by agglutination of NDV-modified human O red blood cells, as well as by immunodiffusion and enzyme immunoassay with various preparations of the virus. These studies clearly demonstrated that the NDV antibodies are distinct from P-B or H-D antibodies. The unexpected observation that guinea pig kidney (GPK) tissues absorbed NDV antibodies allowed their classification into a group of 'GPK-positive' heterophile antibodies. The simultaneous occurrence of the NDV antibodies and H-D antibodies in IM and other diseases suggests the possibility that multiple new antigenic determinants, especially those of carbohydrate nature, may appear due to the alteration of self-antigens as a result of various pathologic processes.</p>  a0020-5915