01553nas a2200289   4500000000100000008004100001260000900042653002700051653001100078653002100089653002000110653001700130653001100147653001200158653000900170653002000179653001300199100001400212700001400226700001200240700001500252245006200267300001000329490000700339520090300346022001401249       1985                            d  c198510aDisease Susceptibility10aFemale10aGenes, Recessive10aGenetic Linkage10aHLA Antigens10aHumans10aleprosy10aMale10aModels, Genetic10aPedigree1 aHaile R W1 aIselius L1 aFine PE1 aMorton N E00aSegregation and linkage analyses of 72 leprosy pedigrees.  a43-520 v353 a<p>Data on 72 families with multiple cases of leprosy were analyzed for a susceptibility gene linked to the HLA loci. We conducted segregation analysis with the program POINTER and identity of HLA types by descent analysis to determine the most likely mode of inheritance. We then conducted linkage analysis with the program LINKAS, first assuming linkage equilibrium and then allowing for linkage disequilibrium and etiological heterogeneity. Segregation results suggest a recessive mode of inheritance, especially for the tuberculoid forms of leprosy. The linkage results, limited to tuberculoid forms and assuming a recessive model, suggest a hypothesis of loose linkage with no unlinked locus. When an additive model is assumed, the best fit is obtained with a hypothesis of complete linkage (theta = 0.0) with heterogeneity. We currently favor the additive model as the more plausible one.</p>  a0001-5652