01661nas a2200385   4500000000100000008004100001260001600042653001200058653002600070653002000096653002700116653002700143653002700170653001100197653001500208653001200223653002600235653001900261653000900280653002500289653001200314653002400326100001300350700001500363700001500378700001500393700001400408700001500422700001600437245005400453300001100507490000800518520073500526022001401261       1985                            d  c1985 Feb 0110aAnimals10aAntibodies, Bacterial10aCercopithecidae10aCercopithecus aethiops10aDisease Models, Animal10aDisease Susceptibility10aFemale10aHaplorhini10aleprosy10aLymphocyte Activation10aMacaca mulatta10aMale10aMycobacterium leprae10aSaimiri10aSpecies Specificity1 aWolf R H1 aGormus B J1 aMartin L N1 aBaskin G B1 aWalsh G P1 aMeyers W M1 aBinford C H00aExperimental leprosy in three species of monkeys.  a529-310 v2273 a<p>Eleven mangabey monkeys inoculated with Mycobacterium leprae developed lepromatous-type leprosy. Nine of the mangabeys were inoculated with M. leprae isolated from a mangabey with naturally acquired lepromatous leprosy. Immune function was depressed in some of these animals after dissemination of the disease. Two mangabeys developed lepromatous leprosy after inoculation with human M. leprae passaged in an armadillo. Three rhesus and three African green monkeys inoculated with mangabey-derived M. leprae also developed lepromatous leprosy. Mangabeys may be the first reported nonhuman primate model for the study of leprosy. Rhesus and African green monkeys may also prove to be reproducibly susceptible to the disease.</p>  a0036-8075