01486nas a2200361   4500000000100000008004100001260001300042653001500055653001000070653001000080653001500090653002100105653002200126653001100148653001100159653001200170653001600182653001400198653001600212653000900228653002500237653001600262653001900278653002500297100001700322700001200339700001400351245006800365300001000433490000700443520066000450022001401110       1985                            d  c1985 Feb10aAdolescent10aAdult10aChild10aEpithelium10aErythema Nodosum10aFacial Dermatoses10aFemale10aHumans10aleprosy10aLymphocytes10aLysosomes10aMacrophages10aMale10aMicroscopy, Electron10aMiddle Aged10aMouth Diseases10aMycobacterium leprae1 aReichart P A1 aMetah D1 aAlthoff J00aUltrastructural aspects of oral and facial lepromatous lesions.  a55-600 v143 a<p>The ultrastructure of 10 lepromatous lesions in the face and the palatal mucosa after different duration and length of treatment was studied. Biopsies taken from patients who showed erythema nodosum leprosum (ENL) revealed different ultrastructural characteristics from those taken from 'burnt out' and non-medicated cases. Multiple secondary lysosomes were rarely seen in non-ENL cases. The presence of Mycobacterium leprae and an increased lysosomal activity in ENL reactive cases is interpreted as a reaction to the lysis of the cytoplasmic matrix of M. leprae; however, drug-specific (diaminodiphenylsulphone) reactions must also be considered.</p>  a0300-9785