01423nas a2200301   4500000000100000008004100001260001700042653001200059653001200071653003100083653000900114653001100123653002300134653001200157653000900169653002500178653001400203100001900217700001300236700002400249700001500273245010600288300001000394490000700404050003200411520066400443022001401107       1985                            d  c1985 Apr-Jun10aAnimals10aDapsone10aDrug Resistance, Microbial10aFoot10aHumans10aLeprostatic Agents10aleprosy10aMice10aMycobacterium leprae10aSerotonin1 aBalakrishnan S1 aMester L1 aVenkataramaniah H N1 aBhatia V N00aMouse foot-pad studies with M. leprae--effect of desoxy fructo serotonin (DFS) and related compounds.  a323-80 v57  aInfolep Library - available3 a<p>Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.</p>  a0254-9395