01168nas a2200217   4500000000100000008004100001260001700042653001200059653001200071653002700083653003100110653001200141653000900153100001300162700001300175245009900188300001000287490000600297520063300303022001400936       1985                            d  c1985 Jul-Sep10aAnimals10aDapsone10aDisease Models, Animal10aDrug Resistance, Microbial10aleprosy10aMice1 aTraore I1 aNebout M00a[Results of animal experimentation activities at the Institut Marchoux in Bamako (1982-1984)].  a255-90 v33 a<p>The Institut Marchoux animal research unit report of activities 1982-1984 shows increasing results in mouse-foods-pads inoculations. Among 17 multibacillary cases, 16 were clinically dapsone-resistant suspected. In 9 cases there was no multiplication; however in 4 cases, multiplication were observed in the untreated controled mice group but no multiplication in dapsone groups. Three cases were fully dapsone-resistant in all concentrations tested. In one case we have detected a partial DDS resistance. No multiplication in the mice group with 10(-2) dapsone dict, but multiplication in 10(-3) and 10(-4) dapsone dict.</p>  a0001-5938