01226nas a2200313   4500000000100000008004100001260001700042653001500059653001000074653001200084653001200096653003100108653000900139653001100148653001200159653000900171653002500180100001600205700001600221700001200237700001100249700002000260245004300280300001100323490000700334050003200341520052500373022001400898       1985                            d  c1985 Jul-Sep10aAdolescent10aAdult10aAnimals10aDapsone10aDrug Resistance, Microbial10aFoot10aHumans10aleprosy10aMice10aMycobacterium leprae1 aVaishnavi C1 aGanguly N K1 aKumar B1 aKaur S1 aChakravarti R N00aPrimary dapsone resistance in leprosy.  a507-130 v57  aInfolep Library - available3 a<p>20 carefully selected untreated patients of bacilliferous leprosy were investigated for primary dapsone resistance by foot pad inoculation. Mice were fed on 0.001 g% and 0.01 g% of dapsone during the period of study. Mice in the control group were given normal rodent feed only. Animals were sacrificed from 6 month onwards at 6 week intervals upto 9 months. In two animals the growth of M. leprae was not inhibited by 0.001 g% concentration of dapsone in diet, but was completely inhibited by 0.01 g% of dapsone.</p>  a0254-9395