01832nas a2200337   4500000000100000008004100001260001300042653001600055653001100071653001100082653001300093653001200106653001600118653001600134653000900150653001400159653002500173653001300198653001800211653001600229653001700245100001500262700001400277700001800291700001400309245016000323300001100483490000700494520097900501022001401480       1985                            d  c1985 Oct10aAge Factors10aFemale10aHumans10aLepromin10aleprosy10aLymphocytes10aMacrophages10aMale10aMonocytes10aMycobacterium leprae10aPedigree10aReceptors, Fc10aSex Factors10aTime Factors1 aMistry N F1 aBirdi T J1 aMahadevan P R1 aAntia N H00aMycobacterium leprae-induced alterations in macrophage Fc receptor expression and monocyte-lymphocyte interaction in familial contacts of leprosy patients.  a415-230 v223 a<p>Macrophage Fc receptor expression and monocyte-lymphocyte interaction in the presence of Mycobacterium leprae were examined in familial contacts of leprosy patients. Defective M phi functions similar to those of borderline and lepromatous patients could be observed in approximately 71% of consanguineous contacts and 43% of spouses of index patients. Although the values in the latter group were markedly lower than those of the consanguineous contacts, they tended to be higher than those of normal individuals (20%). These in vitro M phi functions were independent of age, sex, and age at onset of exposure and were only weakly associated with duration of exposure. The outcome of the monocyte-lymphocyte interaction test paralleled to a large extent the in vivo Mitsuda lepromin response. Four contacts with defective M phi functions also showed signs of leprosy. The value of these in vitro tests as markers of 'susceptibility' could therefore prove significant.</p>  a0300-9475