01710nas a2200337   4500000000100000008004100001260001300042653001200055653002400067653001500091653003800106653001700144653001600161653001100177653001200188653001000200653004500210653002500255653002800280100001200308700001500320700001500335700001500350700001600365245013900381856007800520300001000598490000700608520074300615022001401358       1985                            d  c1985 Oct10aAnimals10aAntigens, Bacterial10aArmadillos10aEnzyme-Linked Immunosorbent Assay10aFormaldehyde10aGlycolipids10aHumans10aleprosy10aLiver10aMycobacterium Infections, Nontuberculous10aMycobacterium leprae10aTuberculosis, Pulmonary1 aIzumi S1 aSugiyama K1 aFujiwara T1 aHunter S W1 aBrennan P J00aIsolation of the Mycobacterium leprae-specific glycolipid antigen, phenolic glycolipid-I, from formalin-fixed human lepromatous liver.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC268496/pdf/jcm00111-0232.pdf  a680-20 v223 a<p>A Mycobacterium leprae-specific phenolic glycolipid antigen was purified from Formalin-fixed liver preserved from an advanced lepromatous leprosy patient. Its chemical and immunological properties were compared with those of phenolic glycolipid-I obtained from M. leprae-infected armadillo liver. Based on the findings that the glycolipids from the two sources have the same thin-layer chromatographic properties, infrared absorption spectrum, sugar composition, and seroreactivity, we conclude that large quantities of the phenolic glycolipid-I antigen are produced in human lepromatous leprosy lesions and that Formalin-fixed lepromatous livers and spleens from the prechemotherapeutic era are suitable sources of the glycolipid.</p>  a0095-1137