01780nas a2200289   4500000000100000008004100001260001700042653001200059653001500071653001100086653003000097653002300127653001300150653001200163653000900175653000900184653002500193100001200218700001600230700001700246245008700263300001100350490000700361050003200368520107600400022001401476       1985                            d  c1985 Oct-Dec10aAnimals10aArmadillos10aFemale10aHypersensitivity, Delayed10aImmunity, Cellular10aLepromin10aleprosy10aLung10aMale10aMycobacterium leprae1 aJob C K1 aSanchez R M1 aHastings R C00aEffect of repeated lepromin testing on experimental nine-banded armadillo leprosy.  a716-270 v57  aInfolep Library - available3 a<p>Twenty-eight armadillos were lepromin tested and infected with M. leprae; 18 intravenously and 10 intradermally. The lepromin test was repeated after 3 months and at intervals of 6 months thereafter until their death or sacrifice up to 30 months. The one animal with tuberculoid lepromin was resistant and 14 of the 16 with lepromatous lepromin developed generalized disease. Of the 11 with borderline lepromin, 6 developed disseminated disease and 5 were resistant. There is a definite relationship between resistance and tuberculoid lepromin in the armadillo. Repeated lepromin testing had no effect in the rate of infection and the course of the disease in animals infected intravenously. In the intradermally infected animals the results were inconclusive. Whereas all the 20 animals with disseminated disease showed lesions in the liver, spleen and lymph nodes, only 4 animals had sciatic nerve involvement. Peripheral nerve trunk is not necessarily the preferred site in the armadillo. Lung lesions were an important cause of death in lepromatous armadillos.</p>  a0254-9395