01386nas a2200265   4500000000100000008004100001260001700042653003100059653003000090653001100120653001200131653001600143653002300159653001300182653002500195653001300220100001600233700001500249245009900264300001000363490000700373050003200380520069400412022001401106       1985                            d  c1985 Oct-Dec10aDrug Resistance, Microbial10aDrug Therapy, Combination10aHumans10aleprosy10aMathematics10aModels, Biological10aMutation10aMycobacterium leprae10aSoftware1 aAlmeida J G1 aChacko C J00aComputerized mathematical model of M. leprae population dynamics during multiple drug therapy.  a780-90 v57  aInfolep Library - available3 a<p>A computerized mathematical model of M. leprae populations during multiple drug therapy (MDT) was constructed. Relevant published information available to date was fed into it, and reasoned assumptions were made. From the model, it seems likely that MDT steadily selects bacteria resistant to the most powerful of the three drugs used: unless the individual bactericidal potencies of the drugs balance one another. If the drugs used have differing potencies, cure probably hinges on treatment being continued until all metabolically active bacteria are killed. Withdrawal of treatment before that could lead to relapse with bacteria resistant to the most powerful of the drugs used.</p>  a0254-9395