01857nas a2200325   4500000000100000008004100001260001300042653001200055653001400067653001100081653003000092653001300122653001700135653002800152653001200180653001000192653000900202653000900211653002100220653003100241653001500272653002000287653001100307100001300318245011500331300001100446490000700457520105300464022001401517       1979                            d  c1979 Sep10aAnimals10aCell Wall10aFemale10aHypersensitivity, Delayed10aImmunity10aImmunization10aImmunization, Secondary10aleprosy10aLiver10aMale10aMice10aMice, Inbred C3H10aMycobacterium lepraemurium10aOrgan Size10aPicryl Chloride10aSpleen1 aTanaka Y00aPartial inhibition of the growth of Mycobacterium lepraemurium in C3H mice immunized with cell wall skeletons.  a486-940 v473 a<p>C3H mice stimulated with M. lepraemurium cell wall skeletons (LM-CWS) were challenged with viable M. lepraemurium, and delayed-type hypersensitivity (DTH) to picryl chloride was measured. In one type of experiment the mice were challenged at the time when stimulation of cell-mediated resistance by means of LM-CWS was undertaken. The major purpose was to investigate principles pertaining to immunotherapy. In contrast to the loss of a detectable DTH response to picryl chloride, development of murine leprosy was partially suppressed. In the second type of experiment the mice were stimulated with oil-attached LM-CWS seven weeks before challenge with M. lepraemurium. Findings were: a) that nonspecific DTH as measured by sensitization and challenge with picryl chloride was activated before the infection with M. lepraemurium and b) that the DTH which developed was associated with partial protection against the growth of lepromata. The murine leprosy which developed in C3H mice stimulated with LM-CWS was progressive after some delay.</p>  a0148-916X