01989nas a2200325   4500000000100000008004100001260001700042653002800059653003000087653001100117653002300128653002400151653001300175653001200188653002000200653001500220653001500235653001600250653001600266100001400282700001400296700001800310700001200328245012600340300001000466490000700476050003200483520113400515022001401649       1985                            d  c1985 Jan-Mar10aAdrenal Cortex Hormones10aCell Migration Inhibition10aHumans10aImmunity, Cellular10aIn Vitro Techniques10aLepromin10aleprosy10aLeukocyte Count10aLeukocytes10aLevamisole10aLymphocytes10aMacrophages1 aKundu S K1 aHazra S K1 aChaudhuri S K1 aNandy A00aImmunomodulation with corticosteroids and levamisole in leprosy as gauged by in vivo lepromin and in vitro CMI responses.  a37-570 v57  aInfolep Library - available3 a<p>Corticosteroids and Levamisole are known to be immuno suppressive and immuno stimulating agents respectively. Their effects on polar types of leprosy, tuberculoid and lepromatous have been studied using in vivo lepromin and in vitro lymphocyte count, rosette formation, L.T.T. and L.M.I.T. parameters. Immunosuppressive effect of corticosteroids on tuberculoid leprosy is marked with reduced and negative lepromin sensitivity but same does not hold true with other in vitro C.M.I. tests. Similar results are obtained with levamisole exhibiting its ineffectiveness in lepromin conversion in lepromatous cases although some improvement is observed in other in vitro C.M.I. tests. Evaluation of the results showed: lack of correlation between in vivo lepromin and in vitro other C.M.I. parameters with corticosteroids and levamisole lepromin sensitivity has some unknown influence other than thymic factors, prolonged corticosteroid therapy may produce permanent immunosuppression in tuberculoid cases making them more vulnerable towards lepromatous pole and lepromin sensitivity is more reliable, stable and easy to perform.</p>  a0254-9395