01826nas a2200241   4500000000100000008004100001260000900042653001100051653003000062653002300092653001300115653001200128653001500140100001500155700001500170700001600185700001800201245008300219300001000302490000700312520125100319022001401570       1985                            d  c198510aHumans10aHypersensitivity, Delayed10aImmunity, Cellular10aLepromin10aleprosy10aTuberculin1 aArruda M S1 aArruda O S1 aAstolfi C S1 aOpromolla D V00a[Fernandez and Mitsuda reactions in patients with leprosy and their contacts].  a23-310 v103 a<p>Hanseniasis patients and contacts of Virchowian patients, totaling 467 persons have been submitted to Mitsuda's reaction. These individuals have been divided into five groups: group 1 compounded of 59 persons, relatives of Virchowian patients; group 2 - 171 persons, employees of the Hospital Lauro de Souza Lima working there for more than one year; group 3 - 127 hanseniasis patients in activity, Mitsuda negative; group 4 - 63 hanseniasis patients in activity, Mitsuda positive; group 5 - 47 Virchowian patients, inactive, Mitsuda negative. The analysis of the data showed that: a) hanseniasis patients, both Mitsuda positive and negative, do not present positivity to Fernandez's reaction; b) early reaction can be observed more frequently in individuals of group 1 than in those of group 2. Mitsuda's antigen causes the reversal of Fernandez's reaction in about 30% of indirect contacts; c) the percentage of negative Mitsuda's reactions (without induration) does not differ between groups 1 and 2, though indurations smaller than 5 mm have been as many as 10 times more frequent in individuals of group 1. A second application of the antigen in Mitsuda negative persons showed the reversal of the test in 100% of the tested subjects.</p>  a0100-3283