02066nas a2200361   4500000000100000008004100001260001300042653001200055653002700067653002900094653002000123653003100143653001200174653002500186653002600211653001600237653002000253653002200273100001500295700001500310700001300325700001500338700001500353700001400368700001600382700001700398700001700415245010400432300001100536490000700547520113600554022001401690       1985                            d  c1985 Jan10aAnimals10aAntibodies, Monoclonal10aAntibody-Producing Cells10aCercopithecidae10aHemolytic Plaque Technique10aleprosy10aLongitudinal studies10aLymphocyte Activation10aLymphocytes10aMonkey Diseases10aPokeweed Mitogens1 aMartin L N1 aGormus B J1 aWolf R H1 aGerone P J1 aMeyers W M1 aWalsh G P1 aBinford C H1 aHadfield T L1 aSchlagel C J00aDepression of lymphocyte responses to mitogens in mangabeys with disseminated experimental leprosy.  a115-300 v903 a<p>Mononuclear cells from mangabey monkeys with disseminated experimental leprosy had increasingly severe depression of blastogenic responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen as the disease progressed. Blastogenic responses were not depressed in cells from mangabeys with more localized disease. Blastogenic responses of cells from normal mangabeys appeared to vary with a circannual rhythm. The demonstration of significant negative correlations between the blastogenic responses to mitogens and the percentages of OKT8+ cells suggested that the mangabey OKT8+ subset may contain cells with suppressor function. The depressed responses to mitogens by cells from monkeys with disseminated experimental leprosy were associated with relatively high percentages of OKT8+ cells. Polyclonal immunoglobulin plaque-forming cell responses to pokeweed mitogen were depressed in cells from experimentally infected mangabeys. The results indicated that defects in immune regulation may occur in experimental leprosy in mangabeys, similar in some respects to the defects that have been reported in human leprosy.</p>  a0008-8749