02200nas a2200493   4500000000100000008004100001260001300042653001200055653002700067653001100094653001900105653002000124653001400144653000800158653001100166653001900177653001600196653002000212653001200232653002600244653000900270653002400279653002500303653001300328653002000341653002500361653000900386653001800395100001500413700001400428700001400442700001600456700001300472700001700485700001700502700001600519700001500535700001300550245006400563300000900627490000700636520104900643022001401692       1985                            d  c1985 Mar10aAnimals10aAntibodies, Monoclonal10aBiopsy10aBlood Proteins10aCercopithecidae10aCytoplasm10aDNA10aFemale10aFreeze Etching10aHistiocytes10aImmunoglobulins10aleprosy10aLymphocyte Activation10aMice10aMice, Inbred BALB C10aMicroscopy, Electron10aMitogens10aMonkey Diseases10aMycobacterium leprae10aSkin10aT-Lymphocytes1 aMeyers W M1 aWalsh G P1 aBrown H L1 aBinford C H1 aImes G D1 aHadfield T L1 aSchlagel C J1 aFukunishi Y1 aGerone P J1 aWolf R H00aLeprosy in a mangabey monkey--naturally acquired infection.  a1-140 v533 a<p>Naturally acquired leprosy was detected in an otherwise normal "sooty" mangabey monkey (Cercocebus atys). This animal was imported from West Africa in 1975 and developed clinical symptoms of leprosy in 1979. Histopathologic findings were those of subpolar-lepromatous to borderline-lepromatous leprosy in the Ridley-Jopling classification. The disease was progressive, with crippling neuropathic deformities of the hands and feet. The disease regressed under specific therapy. The etiologic agent was identified as Mycobacterium leprae by the following criteria: invasion of nerves of host, staining properties, electron microscopic findings, noncultivable on mycobacteriologic media, DOPA-oxidase positive, lepromin reactivity, infection patterns in mice and armadillos, sensitivity to sulfone, and DNA homology. We believe the animal acquired the disease from a patient with active leprosy. The mangabey monkey offers promise as a primate model for leprosy, and adds a third reported species to animals with naturally acquired leprosy.</p>  a0148-916X