01532nas a2200253   4500000000100000008004100001260001300042653001200055653001600067653001200083653000900095653001500104653002500119653002500144653002900169653002200198653001800220100001600238245010600254300000900360490000700369520088800376022001401264       1985                            d  c1985 Mar10aAnimals10aEndothelium10aleprosy10aMice10aMice, Nude10aMicroscopy, Electron10aMycobacterium leprae10aNerve Fibers, Myelinated10aPeripheral nerves10aSchwann Cells1 aFukunishi Y00aElectron microscopic findings of the peripheral nerve lesions of nude mice inoculated with M. leprae.  a75-80 v533 a<p>Peripheral nerve lesions of nude mice inoculated with Mycobacterium leprae were examined from 1 year to 1 year and 8 months post-inoculation. Leprosy bacilli and intracytoplasmic foamy structures were found in the perineurial cells, endothelial cells of capillaries, Schwann cells, and axons of the myelinated nerve fibers inside the lepromas of foot pads. In the proximal portion of the sciatic nerve, bacilli were found chiefly in the macrophages of the endoneurial space. Bacilli were not found in the perineurial cells of the sciatic nerves. Marked fibrosis, hypertrophy or degeneration of Schwann cells, demyelination, axonal damage or irreversible destruction of nerve architecture were not observed clearly. Therefore, it is thought that nude mice inoculated with M. leprae are suitable models for the study of the early peripheral nerve lesions of lepromatous leprosy.</p>  a0148-916X