01976nas a2200301   4500000000100000008004100001260001300042653001500055653001000070653000900080653001100089653001100100653002800111653001200139653000900151653001600160653002500176100001100201700001600212700001500228700002000243245018000263856007800443300001100521490000700532520112100539022001401660       1985                            d  c1985 Apr10aAdolescent10aAdult10aAged10aFemale10aHumans10aImmunoenzyme Techniques10aleprosy10aMale10aMiddle Aged10aBeta 2-Microglobulin1 aSaha K1 aBhatnagar A1 aSharma V K1 aChakrabarty A K00aEnzyme immunoassay of serum beta-2-microglobulin levels in various histological forms of leprosy with special reference to its elevation in type I and type II lepra reactions.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC271746/pdf/jcm00117-0206.pdf  a658-610 v213 a<p>The mean beta-2-microglobulin level in serum (3,362 +/- 2,494 micrograms/liter) for 76 leprosy patients, including 9 borderline-tuberculoid, 8 borderline-borderline, 9 borderline-lepromatous, and 16 lepromatous-lepromatous patients and 34 patients with type I or type II lepra reactions, was significantly higher (P less than 0.001) than that (2,122 +/- 1,844 micrograms/liter) for 35 normal subjects. It decreased significantly (P less than 0.001) as the disease glided down from borderline tuberculoid (3,173 +/- 899 micrograms/liter) to the lepromatous end (1,813 +/- 1,391 micrograms/liter). At the onset of type I or type II reaction, the mean beta-2-microglobulin level in serum increased (4,447 +/- 2,863 micrograms/liter), and it remained unchanged (4,433 +/- 2,623 micrograms/liter) after clinical remission. The beta-2-microglobulin level in serum decreased in 55.5% of the patients tested after subsidence of reaction. The level was significantly higher in patients with type II reactions (5,433 +/- 3,299 micrograms/liter) than in patients with type I reactions (3,558 +/- 2,171 micrograms/liter).</p>  a0095-1137