01651nas a2200313   4500000000100000008004100001260001300042653001200055653001800067653001600085653001300101653003000114653002600144653001200170653000900182653002100191653001800212653001700230653001600247100001100263700001400274700001300288245008500301856009000386300001100476490000700487520082900494022001401323       1985                            d  c1985 Aug10aAnimals10aB-Lymphocytes10aBCG Vaccine10aHindlimb10aHypersensitivity, Delayed10aImmunization, Passive10aleprosy10aMice10aMice, Inbred CBA10aT-Lymphocytes10aTime Factors10aVaccination1 aLowe C1 aBrett S J1 aRees R J00aAdoptive cell transfer of resistance to Mycobacterium leprae infections in mice.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577294/pdf/clinexpimmunol00131-0120.pdf  a336-420 v613 a<p>Cells were transferred from mice intradermally vaccinated with killed Mycobacterium leprae to sublethally irradiated recipients. Unseparated cells from lymph nodes or spleens of M. leprae vaccinated mice were found to cause significant inhibition of the growth of a subsequent M. leprae challenge in mouse footpads for up to 26 weeks after vaccination. Vaccination with live BCG and cells transferred from BCG-vaccinated mice caused no significant inhibition of M. leprae growth in mouse footpads. Cell separation into fractions containing predominantly B and T lymphocytes showed that the inhibition of growth was due to M. leprae-sensitized T lymphocytes. M. leprae vaccinated mice were also skin tested with soluble M. leprae antigen and showed maximum delayed hypersensitivity responses 4 weeks after vaccination.</p>  a0009-9104