01436nas a2200265   4500000000100000008004100001260000900042653001200051653002700063653002100090653002300111653002200134653001200156653001600168653000900184653002400193653002900217653003100246100001600277245016900293300001000462490000700472520067700479022001401156       1979                            d  c197910aAnimals10aDisease Models, Animal10aImmune Tolerance10aImmunity, Cellular10aImmunosuppression10aleprosy10aMacrophages10aMice10aMice, Inbred BALB C10aMycobacterium Infections10aMycobacterium lepraemurium1 aPreston P M00aSerum from infected mice suppresses macrophage-mediated immunity in Mycobacterium lepraemurium infection: a model for imparied macrophage immunity in human leprosy.  a212-50 v733 a<p>Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice.</p>  a0035-9203