01505nas a2200289   4500000000100000008004100001260001300042653001200055653002400067653001500091653001600106653002300122653002700145653002100172653001700193653001100210653001200221653000900233653002500242653001300267245011500280856009000395300000800485490000700493520070100500022001401201       1979                            d  c1979 Apr10aAnimals10aAntigens, Bacterial10aArmadillos10aBCG Vaccine10aBacterial Vaccines10aDisease Models, Animal10aErythema Nodosum10aHLA Antigens10aHumans10aleprosy10aMice10aMycobacterium leprae10aResearch00aResearch in leprosy. A report of a committee set up by the medical research council to study future prospects.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1537685/pdf/clinexpimmunol00205-0009.pdf  a1-70 v363 a<p>Recommendations for future research in leprosy include (i) cultivation of M. leprae in vitro; (ii) genetic control of susceptibility, including twin studies and HLA typing; (iii) precise antigenic analysis of M. leprae; (iv) mechanisms involved in the macrophage response to mycobacterial infections; (v) more use of experimental models such as normal mice infected with M. lepraemurium; (vi) reassessment of the protection afforded by BCG; (vii) assessment of protection afforded by killed (armadillo) M. leprae vaccine; (viii) pathogenesis of erythema nodosum leprosum including a study of the effect of thalidomide; and (ix) development of in vitro systems for drug sensitivity testing.</p>  a0009-9104