00859nas a2200217   4500000000100000008004100001260001700042653001200059653001200071653003300083653001200116653001200128100001700140700001500157245009000172300001100262490000700273050003200280520031500312022001400627       1985                            d  c1985 Oct-Dec10aAnimals10aDapsone10aDrug Evaluation, Preclinical10aleprosy10aRabbits1 aKulkarni V M1 aMishra D S00aChemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone.  a756-620 v57  aInfolep Library - available3 a<p>Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.</p>  a0254-9395