01744nas a2200397   4500000000100000008004100001260001700042653001500059653001000074653000900084653002200093653001000115653002300125653002200148653001100170653001400181653001100195653001200206653000900218653001600227653002800243653000900271653002100280653002300301653001800324653001000342100001300352700001700365700001300382245008400395300001100479490000700490050003200497520080300529022001401332       1986                            d  c1986 Apr-Jun10aAdolescent10aAdult10aAged10aAged, 80 and over10aChild10aDimethyl Sulfoxide10aDrug Combinations10aFemale10aHistamine10aHumans10aleprosy10aMale10aMiddle Aged10aNervous System Diseases10aPain10aPain Measurement10aSensory Thresholds10aThermosensing10aTouch1 aJain G L1 aPasricha J S1 aGuha S K00aAn attempt to reduce the loss of pain and touch sensations in leprosy patients.  a225-320 v58  aInfolep Library - available3 a<p>An attempt was made to improve the perception of pain and touch sensations at the leprosy lesions. The loss of pain and touch sensations in a lesion was graded using Pain/Touch-Sensation-Testing-and-Grading devices. Application of a solution containing 1 mg of histamine per ml of DMSO, at the affected area decreased the grades of the loss of pain sensation in 11 (31.4%) patients and of touch sensation in 8 (22.8%) patients, out of the 35 patients tested, indicating an improvement in the perception at the lesion. This effect, however, did not persist even for 5 minutes. A higher concentration (2 mg/ml) of histamine produced reduction in the sensory loss in a larger percentage (47% for pain and 35.3% for touch) of patients, though the duration of this effect was still not prolonged.</p>  a0254-9395