01619nas a2200301   4500000000100000008004100001260001700042653001000059653001600069653001200085653003000097653001100127653002300138653001200161653000900173653001600182653001300198100001400211700001400225700002200239700001400261245006500275300001100340490000700351050003200358520091300390022001401303       1986                            d  c1986 Apr-Jun10aAdult10aClofazimine10aDapsone10aDrug Therapy, Combination10aHumans10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aRifampin1 aBhate R D1 aGupta C M1 aChattopadhyay S P1 aSingh I P00aExperience with multidrug therapy in paucibacillary leprosy.  a244-500 v58  aInfolep Library - available3 a<p>Eighty paucibacillary leprosy cases were randomly put on two different multidrug regimens for 6 months followed by dapsone monotherapy. Regimen I was according to WHO (1982) recommendations consisting of Dapsone and six once a month rifampicin. In regimen II in addition to above two constituents, clofazimine was added 100 mg on alternate days. Dapsone thereafter was continued in both the regimens upto one year. The efficacy, acceptability and side effects of multidrug regimens were observed for a period of one year. Histopathological assessment was done on completion of multidrug therapy in all cases. A comparative evaluation of effect of two multidrug regimens in paucibacillary leprosy patients is reported. Addition of clofazimine over WHO (1982) recommended regimen appears to have no added benefit. The duration of WHO (1982) recommended regimens was found to be inadequate in many cases.</p>  a0254-9395