01330nas a2200277   4500000000100000008004100001260001300042653001200055653001500067653001100082653001400093653002300107653001200130653001600142653002500158653002700183653001700210653001400227100001900241700002300260245008600283300001100369490000800380520065000388022001401038       1987                            d  c1987 Mar10aAnimals10aArmadillos10aBiopsy10aEpidermis10aHistocytochemistry10aleprosy10aMacrophages10aMicroscopy, Electron10aRemission, Spontaneous10aTime Factors10aXenarthra1 aIushchenko A A1 aVishnevetskiĭ F E00a[Histochemical study of reverse reactions in experimental leprosy in armadillos].  a376-800 v1033 a<p>Morphological and histochemical characteristics of reverse reactions in M. leprae-infected armadillos are reviewed. The reverse reactions develop in generalized lepromatous disease and are characterized by a dramatic decrease in mycobacterial macrophage load and the appearance of lymphocytes, epithelioid and giant multinuclear cells with peripheral nucleus distribution. Histochemical investigation has shown a decrease in the activity of redox enzymes and alpha-naphthyl acetate esterase and an increase in beta-glucuronidase activity. The reverse reactions in the liver are accompanied by hepatic granuloma and hepatocyte destruction.</p>  a0365-9615