01259nas a2200277   4500000000100000008004100001260001300042653001000055653002200065653002400087653001100111653002900122653001200151653000900163653002100172653001300193653001900206100001300225700001500238700001500253245005600268300001000324490000700334520062600341022001400967       1979                            d  c1979 Jun10aAdult10aBlood Coagulation10aChromatography, Gel10aHumans10aImmunosorbent Techniques10aleprosy10aMale10aProthrombin Time10aThrombin10aThromboplastin1 aCole F S1 aBrusch J L1 aTalarico L00aA circulating anticoagulant in lepromatous leprosy.  a121-50 v473 a<p>We observed a patient with lepromatous leprosy and a circulating anticoagulant. Intrinsic pathway inhibition was demonstrated by prolongation of the activated partial thromboplastin time. Extrinsic pathway inhibition was demonstrated by prolongation of the prothrombin time when performed with diluted thromboplastin. A plasma co-factor was required for inhibition. Immunoadsorption with specific antisera and Sephadex G-200 fractionation suggested that the anticoagulant was an IgM immunoglobulin. The similarities between this patient's anticoagulant and those associated with other disease states are discussed.</p>  a0148-916X