01264nas a2200241   4500000000100000008004100001260001700042653001200059653001500071653001200086653002700098653001100125653001200136653000900148653001400157100001500171245008400186300001000270490000700280050003200287520068900319022001401008       1986                            d  c1986 Jan-Mar10aAnimals10aArmadillos10aDapsone10aDisease Models, Animal10aFemale10aleprosy10aMale10aXenarthra1 aDhople A M00aArmadillo as a model for studying chemotherapy of leprosy: preliminary studies.  a19-280 v58  aInfolep Library - available3 a<p>In order to determine the suitability of the armadillos as a model of human leprosy for chemotherapeutic studies, especially in evaluating newer anti-leprosy drugs, uninfected Armadillos were used to study the metabolic disposition of DDS. Serum DDS levels ranged from 500 ng/ml at 3 hours to 13 ng/ml at 96 hours after intravenous administration of DDS (1 mg/kg). In an ad libitum feeding trial of DDS it was found that the level of serum DDS varied according to the dose of DDS, and even at a dose of 0.0001%, the animals maintained MIC of DDS against M. leprae. Finally, it was demonstrated that armadillos acetylate DDS to MADDS and 7-9% of DDS is acetylated by armadillos.</p>  a0254-9395