01873nas a2200337   4500000000100000008004100001260001300042653001200055653002700067653001100094653002300105653001300128653001200141653001900153653000900172653001300181653000900194100001500203700001500218700001500233700001300248700001500261700001400276700001500290700001600305245004100321300001100362490000700373520114100380022001401521       1986                            d  c1986 Sep10aAnimals10aDisease Models, Animal10aFemale10aImmunity, Cellular10aLepromin10aleprosy10aMacaca mulatta10aMale10aNecrosis10aSkin1 aBaskin G B1 aGormus B J1 aMartin L N1 aWolf R H1 aWatson E A1 aWalsh G P1 aMeyers W M1 aBinford C H00aThe lepromin test in rhesus monkeys.  a427-360 v543 a<p>The lepromin test was studied in rhesus monkeys. Six control monkeys which had not been inoculated with Mycobacterium leprae, six monkeys with experimentally induced leprosy, and nine monkeys which had been inoculated with M. leprae but had not developed leprosy were evaluated with 1X, 10X, and 15X lepromin A, with 1X and 10X lepromin M (mangabey monkey derived), with 1X and 25X purified inactivated M. leprae, and with an armadillo mock lepromin. We found that the lepromin test is useful in rhesus monkeys, but that a higher concentration of antigen than is used in humans is required to induce a response in monkeys. Control monkeys appear to be lepromin negative. Animals which have been inoculated and which develop lepromatous leprosy are also negative. Monkeys which are experimentally inoculated with M. leprae and do not develop leprosy become lepromin positive. Monkeys with indeterminate leprosy have reactions intermediate between lepromatous and resistant animals. No monkeys reacted to armadillo tissue. Our results indicate that 10X lepromin A is a useful preparation for the lepromin testing of rhesus monkeys.</p>  a0148-916X