01201nas a2200229   4500000000100000008004100001260001300042653001100055653001200066653001600078653001500094653002500109653000900134100001600143700001400159700001300173245007500186300001200261490000700273520067700280022001400957       1978                            d  c1978 Sep10aHumans10aleprosy10aMacrophages10aMuramidase10aMycobacterium leprae10aSkin1 aYamashita K1 aIwamoto T1 aIijima S00aImmunohistochemical observation of lysozyme in macrophages in leprosy.  a697-7030 v283 a<p>Lysozyme activities of skin granulomas of 24 patients in leprosy were studied. Lepra cells of all 15 lepromatous leprosy showed strong lysozyme activity in cytoplasma. In the specimens stained with lysozyme and Ziehl-Neelsen's carbolfuchsin double stain conspicuous lysozyme activity around M. leprae were observed. One borderline case was negative. Lysozyme of epithelioid cells and giant cells of 10 tuberculoid types were completely negative. These results suggest that lysozyme plays only a small role in the disposal of M. leprae in macrophages and other mechanisms than bacteriolytic function of lysozyme are responsible for the defence against these bacilli.</p>  a0001-6632