01452nas a2200229   4500000000100000008004100001260001300042653001200055653001100067653001100078653001200089653000900101653002300110653002400133100001800157700001700175245014100192300000900333490000700342520085900349022001401208       1986                            d  c1986 Mar10aDapsone10aFemale10aHumans10aleprosy10aMale10aPatient Compliance10aSelf Administration1 aHuikeshoven H1 aMadarang M G00aSpot test for detection of dapsone in urine: an assessment of its validity and interpretation in monitoring dapsone self-administration.  a21-40 v543 a<p>This study aimed to assess the validity and interpretation of the spot test for monitoring dapsone self-administration that employs filter paper impregnated with a modified Ehrlich's reagent. Urine specimens obtained from 20 volunteers, who took 100 mg dapsone for four days in succession, were investigated by this test. Findings indicate that spot tests will be negative after an average of three missed doses of dapsone, if compared with a standard of 5 micrograms dapsone per ml of urine. No negative spots are expected in fully compliant patients, and no positive spots are expected in patients who did not take dapsone for a week or longer. In the context of the treatment goal, it is argued that this degree of sensitivity makes the spot test a valid tool for the monitoring and management of patient compliance in leprosy control programs.</p>  a0148-916X