01567nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653001600080653001100096653001300107653001200120653002600132653000900158653001600167653002400183100001400207700001700221700001700238700001500255700001200270700001300282700002100295245012100316300001100437490000700448520077200455022001401227       1986                            d  c1986 Mar10aAdolescent10aAdult10aBCG Vaccine10aHumans10aLepromin10aleprosy10aLymphocyte Activation10aMale10aMiddle Aged10aPhytohemagglutinins1 aBrown A E1 aVithayasai V1 aScollard D M1 aNelson K E1 aMoses V1 aSchauf V1 aMakonkawkeyoon S00aLymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration.  a104-100 v173 a<p>The lymphocyte hyporesponsiveness to M. leprae of patients with active lepromatous leprosy has been well described. This immune defect is less well understood in terms of its time of origin, possible reversibility and specificity. To further examine the persistence and specificity of this abnormality, lymphocyte transformation tests of 93 leprosy patients to lepromin, BCG and PHA were studied. Among lepromatous patients, a decreased response to M. leprae was seen, whether the disease was active or inactive. Decreased responses to BCG were found in lepromatous patients with active disease, but not in those with inactive disease. The duration of patient symptoms was not associated with differences in LTT responses among the active lepromatous patients.</p>  a0125-1562