01014nas a2200229   4500000000100000008004100001260001700042653001000059653004300069653001600112653001100128653001200139653000900151100001000160700001300170700001300183245010500196300001100301490000700312520045100319022001400770       1986                            d  c1986 May-Jun10aAdult10aChemical and Drug Induced Liver Injury10aEthionamide10aHumans10aleprosy10aMale1 aSee A1 aHervio P1 aBouvry M00a[The hepatotoxicity of ethionamide remains a topical subject. Apropos of a case of acute hepatitis].  a129-300 v223 a<p>The authors discuss the case of a 22 year-old patient treated for lepromatous leprosy who developed acute hepatitis 2 years after beginning polychemotherapy associating thalidomide, rifampin, ethionamide and clofazimine. Besides the ethionamide, there was no hepato-toxic factor and the hepatic anomalies quickly disappeared upon termination of treatment with this product. This again draws attention to the hepato-toxicity of ethionamide.</p>  a0066-2070