01200nas a2200277   4500000000100000008004100001260001300042653001500055653001000070653000900080653002100089653001100110653001200121653001600133653001500149653001600164100001600180700001600196700001500212245011200227856004100339300001000380490000700390520051100397022001400908       1986                            d  c1986 Jun10aAdolescent10aAdult10aAged10aErythema Nodosum10aHumans10aleprosy10aLymph Nodes10aLymphedema10aMiddle Aged1 aStanley J N1 aPearson J M1 aRidley D B00aEpisodic edema in type 2 lepra reaction can be caused by transient lymphatic obstruction in the lymph node.  uhttp://ila.ilsl.br/pdfs/v54n2a01.pdf  a231-50 v543 a<p>Fourteen patients with lepromatous leprosy developed attacks of edema of the hands and/or feet associated with attacks of type 2 lepra reaction (erythema nodosum leprosum). The regional lymph nodes were enlarged and often tender when edema was present. Lymph node biopsies in five cases showed compression of the subcapsular sinus against the thickened fibrotic capsule of the inflamed node. It is suggested that this obstructs the inflow of lymph into the regional nodes, thereby causing the edema.</p>  a0148-916X