01153nas a2200241   4500000000100000008004100001260000900042653002000051653002200071653000900093653001100102653001600113653001200129653001500141653001600156100001700172700001400189245010300203300001000306490000700316520057400323022001400897       1987                            d  c198710aBone Resorption10aFollow-Up Studies10aHand10aHumans10aHypesthesia10aleprosy10aOsteolysis10aRadiography1 aMacMoran J W1 aBrand P W00aBone loss in limbs with decreased or absent sensation: ten year follow-up of the hands in leprosy.  a452-90 v163 a<p>Three hundred and sixty-seven patients with insensitive hands have been studied by correlating radiologic findings with occupational and medical history in order to better define causal factors in bone resorption. This study indicates that nonspecific infection and trauma are the reasons for bone resorption in 98% of cases. The role of intermittent pressure seems to be in soft tissue breakdown, which then allows bone to become infected. Bone resorption can be arrested at any stage of the disease by appropriate therapy of splinting and control of infection.</p>  a0364-2348