01091nas a2200217   4500000000100000008004100001260000900042653001300051653002100064653002900085653002000114653001700134653001100151653001200162100001700174245007800191300001100269490000600280520057300286022001400859       1987                            d  c198710aBiometry10aGenes, Recessive10aGenetic Diseases, Inborn10aGenetic Linkage10aHLA Antigens10aHumans10aleprosy1 aMajumder P P00aFurther tests of nonrandom segregation with special reference to linkage.  a387-910 v43 a<p>For an autosomal recessive disease, a statistical procedure is developed for detecting nonrandom segregation of marker haplotypes from an unaffected parent to affected children, specifically for the case when the alternative hypothesis of linkage between the disease and marker loci is postulated. The test procedure is locally most powerful and, depending on family size and number of families sampled, any one of the three test statistics proposed can be used. An application of this procedure provides evidence of linkage between tuberculoid leprosy and HLA.</p>  a0741-0395