01745nas a2200313   4500000000100000008004100001260001300042653002700055653001900082653001700101653001900118653002000137653001100157653001000168653001300178653001200191653000900203100001200212700001300224700001500237700001500252700001200267700001500279245003200294300001100326490000700337520107300344022001401417       1987                            d  c1987 Mar10aDisease Susceptibility10aGene Frequency10aHLA Antigens10aHLA-D Antigens10aHLA-DR Antigens10aHumans10aKorea10aLepromin10aleprosy10aRisk1 aKim S J1 aChoi I H1 aDahlberg S1 aNisperos B1 aKim J D1 aHansen J A00aHLA and leprosy in Koreans.  a146-530 v293 a<p>HLA antigens in 157 unrelated Koreans with leprosy have been identified and compared with 162 healthy Korean controls. The patient group consisted of 124 with lepromatous leprosy and 33 with tuberculoid leprosy. Although no significant differences were detected between the two patient groups, several antigens were found to be increased in the combined patient group compared to healthy controls. Two Class I antigens were increased: HLA-A11 (22% vs 12%) and Aw33 (27% vs 14%). Four Class II antigens were increased: HLA-DR1 (16% vs 7%), DR2 (39% vs 21%), DRw9 (14% vs 6%) and DQw1 (74% vs 55%). HLA-DR4 (28% vs 48%), DRw53 (46% vs 69%) and DQw3 (50% vs 75%) in contrast were significantly decreased in patients. Interaction of DR1, DR2, DRw9 and DQw1 as risk factors was analyzed. HLA-DR2 appeared to be the strongest risk factor. No evidence for synergy between DR1, DR2 and DRw9 was detected. DQw1 was not significantly increased in patients in the absence of DR1 and DR2, and thus it was not apparent in this study that DQw1 was an independent risk factor.</p>  a0001-2815