01406nas a2200289   4500000000100000008004100001260001300042653001100055653001200066653000900078653002500087653001600112653001700128653002900145653001800174653001800192653001600210100001400226700001200240700001900252700001400271245012200285300001000407490000700417520067800424022001401102       1987                            d  c1987 Jun10aHumans10aleprosy10aMale10aMicroscopy, Electron10aMiddle Aged10aNerve Fibers10aNerve Fibers, Myelinated10aSchwann Cells10aSpinal Nerves10aSural Nerve1 aGibbels E1 aHenke U1 aKlingmüller G1 aHaupt W F00aMyelinated and unmyelinated fibers in sural nerve biopsy of a case with lepromatous leprosy--a quantitative approach.  a333-70 v553 a<p>A 64-year-old Cambodian male with lepromatous leprosy of several months' duration, with only brief previous treatment, had symmetrical patchy loss of pain and thermal sensibility including the lateral foot regions. Quantitative assessment by light and electron microscopy revealed normal counts of myelinated fibers (MF) and an increased number of unmyelinated fibers (UF). The respective abnormal histograms and the qualitative differentiation of UF-associated Schwann cells suggested a combination of segmental demyelination with Wallerian degeneration of MF, and a loss of genuine UF, concomitant with considerable regenerative activity of both fiber populations.</p>  a0148-916X