02166nas a2200445   4500000000100000008004100001260001700042653001500059653001000074653001000084653002100094653002100115653001100136653002300147653001400170653001100184653001100195653002000206653001100226653001200237653000900249653001600258653001600274653001900290100001200309700001300321700001500334700001200349700001500361700001500376700001600391700001400407700001400421245005000435300001100485490000700496050003200503520117100535022001401706       1986                            d  c1986 Oct-Dec10aAdolescent10aAdult10aChild10aChild, Preschool10aErythema Nodosum10aFemale10aGlomerulonephritis10aHematuria10aHumans10aInfant10aInfant, Newborn10aKidney10aleprosy10aMale10aMiddle Aged10aProteinuria10aPyelonephritis1 aNigam P1 aPant K C1 aKapoor K K1 aKumar A1 aSaxena S P1 aSharma S P1 aMukhija R D1 aGupta A K1 aDubey A L00aHisto-functional status of kidney in leprosy.  a567-750 v58  aInfolep Library - available3 a<p>A study of 64 cases of leprosy (44 lepromatous and 20 nonlepromatous) revealed that the duration of the disease has a significant relationship with renal involvement (chi 2 = 16.9, P less than 0.001). Proteineuria, microscopic haematuria, granular and hyaline casts are mainly seen in lepromatous cases and specially with lepra reaction (100%) while few of the non-lepromatous (2%) cases may show these abnormalities. Impaired renal functions are mostly observed in lepromatous leprosy (62.9%) specially those with lepra reaction (100%) while 2% nonlepromatous cases have these impaired renal functions. Histo-pathological studies revealed non-specific changes in 44.4% of cases and those of chronic pyelonephritis in 15.5% of the cases. Renal amyloidosis is less common occurrence (4.4%). The specific lesion, that is 'leproma kidney', is rare and seen in one patient only. Acid fast bacilli could not be seen in any of the kidney tissue. It is therefore, concluded that the renal involvement in the form of inflammatory lesions and non-specific changes in the glomeruli and tubules are very common in lepromatous leprosy specially during the reactive phase.</p>  a0254-9395