01480nas a2200361   4500000000100000008004100001260001300042653001500055653001000070653000900080653002200089653002800111653002500139653002000164653001800184653002800202653001100230653003500241653001100276653001200287653000900299653001600308653002400324100001500348700001400363700001600377700001800393245006300411300001100474490000700485520061200492022001401104       1987                            d  c1987 Feb10aAdolescent10aAdult10aAged10aAged, 80 and over10aAntibodies, Antinuclear10aAntibody Specificity10aCross Reactions10aCryoglobulins10aDiagnosis, Differential10aFemale10aFluorescent Antibody Technique10aHumans10aleprosy10aMale10aMiddle Aged10aProspective Studies1 aMiller R A1 aWener M H1 aHarnisch JP1 aGilliland B C00aThe limited spectrum of antinuclear antibodies in leprosy.  a108-100 v143 a<p>Sera from 46 consecutive patients with leprosy were collected and tested against an extensive panel of defined nuclear antigens. Antinuclear antibodies (ANA) were present in 16% of patients, but the titer was uniformly low and there was no consistent fluorescence pattern. None of the ANA positive sera contained antibodies which reacted with native DNA, or which were directed against histones, centromeres, SSB, Sm, or ribonucleoprotein. These more specific autoantibody assays thus retained their clinical utility in the differential diagnosis of rheumatologic complaints in patients with leprosy.</p>  a0315-162X