01422nas a2200349 4500000000100000008004100001260001300042653001200055653002700067653001200094653001000106653002100116653001900137653000900156653002200165653002300187653000900210100001500219700001500234700001500249700001300264700001900277700001400296700001600310700001500326700001300341245006400354300001100418490000700429520062200436022001401058 1987 d c1987 Mar10aAnimals10aDisease Models, Animal10aleprosy10aLiver10aLymphatic System10aMacaca mulatta10aMale10aPeripheral nerves10aRespiratory System10aSkin1 aBaskin G B1 aGormus B J1 aMartin L N1 aWolf R H1 aMurphey-Corb M1 aWalsh G P1 aBinford C H1 aMeyers W M1 aMalaty R00aExperimental leprosy in a rhesus monkey: necropsy findings. a109-150 v553 a

A 6-month-old male rhesus monkey (Macaca mulatta) was inoculated intravenously and intracutaneously with Mycobacterium leprae obtained from a naturally infected mangabey monkey. The animal developed generalized lepromatous leprosy, and was killed for pathological examination 56 months after inoculation. Lesions were observed in the skin, nasal mucosa, peripheral nerves, and peripheral lymph nodes, with relative sparing of viscera. The monkey was carefully evaluated for the retrovirus STLV-III infection and was found negative. The rhesus monkey thus provides another animal model for the study of leprosy.

 a0148-916X