02875nas a2200469   4500000000100000008004100001260001300042653001500055653001000070653002100080653002800101653001000129653002100139653003300160653003000193653001100223653001100234653001400245653001000259653002300269653001200292653000900304653001600313653001500329653002600344653002000370653002100390653003000411653002100441653001800462653002200480100001300502700001300515700001200528245017600540856005100716300001000767490000700777050003200784520157500816022001402391       2005                            d  c2005 Jun10aAdolescent10aAdult10aAge Distribution10aChi-Square Distribution10aChild10aChild, Preschool10aCommunicable Disease Control10aDrug Therapy, Combination10aFemale10aHumans10aIncidence10aIndia10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aRegistries10aRetrospective Studies10aRisk Assessment10aRural Population10aSeverity of Illness Index10aSex Distribution10aSurvival Rate10aTreatment Outcome1 aPandey A1 aUddin JM1 aPatel R00aEpidemiological shift in leprosy in a rural district of central India following introduction of multi-drug therapy (April 1986 to March 1992 and April 1992 to March 2002).  uhttps://leprosyreview.org/article/76/2/11-2118  a112-80 v76  aInfolep Library - available3 a<p>This study compares the epidemiological pattern of leprosy in pre- (April 1986 to March 1992) and post- (April 1992 to March 2002) multi-drug therapy (MDT) periods by retrospective analysis of 3274 registered leprosy cases in the rural field area of Regional Leprosy Training & Research Institute (RLTRI), situated in Raipur district of Chattisgarh province of Central India. The area has high endemicity for leprosy. In the post-MDT period, prevalence rate (PR) came down to less than 1 in 10, while New Case Detection Rate (NCDR) remained almost static during the two periods. Of the total new registered cases, 30.1% were registered during the pre-MDT period and the remaining 69.9% during the post-MDT period. Comparison of key leprosy variables among new registered cases showed a 2-fold rise in the proportion of MB cases (14.8 versus 27.6%), 3.0% increase in proportion of child cases (15.3 versus 18.6%) and cases with deformity grade II (3.1 versus 5.9%) and 4.0% increase in female proportion (41.4 versus 45.7%) during the post-MDT period. A decline was noted in mean age of registration for both MB (6.4 years) and PB (5.7 years) groups in the post-MDT period. While comparing treatment and outcome related variables, a marked fall of 25.8 months was recorded in treatment duration in the post-MDT period. The defaulter rate came down by 45.0% and relapse rate by more than 12.0% during the same period. The study shows that MDT is effective operationally, but continued ongoing transmission of infection and delayed diagnosis needs corrective action.</p>  a0305-7518