01263nas a2200265   4500000000100000008004100001260001300042653002300055653002800078653002700106653002000133653002100153653001700174653001100191653001200202653003700214653001300251100001500264700001500279245002300294300001000317490000700327520064900334022001400983       1986                            d  c1986 Jun10aChromosome Mapping10aDiagnosis, Differential10aDisease Susceptibility10aGenes, Dominant10aGenes, Recessive10aHLA Antigens10aHumans10aleprosy10aMajor Histocompatibility Complex10aPedigree1 aDemenais F1 aFeingold N00a[HLA and leprosy].  a735-70 v343 a<p>Although there is now accumulating evidence that the host response to Mycobacterium leprae is genetically controlled, the nature of the genetic component is still imprecise. Case-control studies as well as family studies, in various populations, have shown that HLA linked factors confer susceptibility to tuberculoid leprosy and lepromatous leprosy respectively. Recently, associations between Gm allotypes and the disease have also been reported. Further studies of the familial cosegregation of the different forms of leprosy together with the HLA and Gm markers may permit a better understanding of the underlying genetic mechanisms.</p>  a0369-8114