02098nas a2200349   4500000000100000008004100001260001300042653001200055653002400067653002000091653002000111653001000131653001700141653001200158653002600170653000900196653002500205653001800230653002500248653003200273653001800305100002200323700001300345700001600358700001500374245008400389856004100473300001100514490000700525520120200532022001401734       1986                            d  c1986 Sep10aAnimals10aAntigens, Bacterial10aCells, Cultured10aCross Reactions10aGenes10aImmunization10aleprosy10aLymphocyte Activation10aMice10aMice, Inbred Strains10aMycobacterium10aMycobacterium leprae10aNontuberculous Mycobacteria10aT-Lymphocytes1 aDouglas-Jones A G1 aWade S M1 aVaughan R H1 aWatson J D00aImmunity to leprosy. IV. Murine T-cell proliferative responses to mycobacteria.  uhttp://ila.ilsl.br/pdfs/v54n3a01.pdf  a367-790 v543 a<p>The nature of antigens shared between Mycobacterium leprae and other species of mycobacteria has been examined using a murine T-cell proliferation assay. Mice were immunized with different mycobacteria, and lymph node cultures were prepared one week later and challenged with M. leprae antigen. The 13 species of mycobacteria tested as antigens in this assay revealed that several species shared antigens in common with M. leprae as recognized by T-cell responses. C57BL/10J mice and congenic strains exhibit differences in T-cell responsiveness to M. leprae. B10.M and B10.Q mice are high responders and C57BL/10J are low responders, while F1 (C57BL/10J X B10.M) and (C57BL/10J X B10.Q) hybrid progeny are also low responders. These genetic differences were not observed when six other mycobacterial species were used as T-cell antigens. An unexpected finding was that the genetic pattern of T-cell responsiveness to M. marinum was identical to that observed for M. leprae using these strains of mice. Helper T cells may recognize antigenic determinants shared by M. leprae and M. marinum. These antigens may initiate the induction of T-cell responses to these two species of mycobacteria.</p>  a0148-916X