01736nas a2200301   4500000000100000008004100001260001300042653001500055653001000070653003000080653002100110653001100131653001200142653001500154653001600169653002500185653002400210653001500234653001800249653002000267100001200287700001200299245009500311300001000406490000700416520099700423022001401420       1987                            d  c1987 Mar10aAdolescent10aAdult10aCell Migration Inhibition10aErythema Nodosum10aHumans10aleprosy10aLeukocytes10aMiddle Aged10aMycobacterium leprae10aPhytohemagglutinins10aSkin Tests10aT-Lymphocytes10aTuberculin Test1 aRao T D1 aRao P R00aEnhanced cell-mediated immune responses in erythema nodosum leprosum reactions of leprosy.  a36-410 v553 a<p>Cell-mediated immune (CMI) responses were measured in 39 lepromatous, 44 erythema nodosum leprosum (ENL), and 22 post-ENL patients. The leukocyte migration inhibition test was used to measure CMI responses to mitogen phytohemagglutinin-P (PHA), crossreacting antigen purified protein derivative (PPD) of tuberculin, and armadillo-derived whole and sonicate Mycobacterium leprae. "Early T" lymphocytes of the peripheral blood were also enumerated using the rosetting technique. Significantly enhanced immune responses (lower migratory indices) were found to whole M. leprae during ENL. Although responses were high with PHA and PPD, they were identical in all of the groups, indicating that during ENL reaction M. leprae-specific responses are enhanced. "Early T" lymphocytes also showed a significant increase in ENL reactions compared to lepromatous patients. However, there was no response to the leprolin skin test in ENL patients in contrast to the enhanced in vitro CMI responses.</p>  a0148-916X