02137nas a2200301   4500000000100000008004100001260001700042653001500059653001000074653001600084653001600100653002500116653001000141653001100151653001100162653001000173653001200183653000900195653001600204100001400220700001300234700001500247245015000262300001000412490000700422520139200429022001401821       2007                            d  c2007 Apr-Jun10aAdolescent10aAdult10aAge Factors10aBCG Vaccine10aCase-Control Studies10aChild10aFemale10aHumans10aIndia10aleprosy10aMale10aSex Factors1 aRahete NP1 aZodpey S1 aKamble K M00aEffectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of leprosy: a population-based case-control study in Raipur, India.  a86-900 v513 a<p><b>OBJECTIVE: </b>To estimate the effectiveness of BCG vaccination in the prevention of leprosy.</p><p><b>METHODS: </b>study design: Population-based pair-matched case-control study. The study was carried out in the field operation area of Regional Leprosy Training and Research Centre, Raipur, Chattisgarh, India. It included 201 cases of leprosy (diagnosed by WHO criteria), born onwards 1964. Each case was pair-matched with one neighbourhood control for age and sex. BCG vaccination status was assessed by examination for the presence of BCG scar, immunization records if available and information from subjects/parents of children. Subjects uncertain about BCG vaccination were not included.</p><p><b>RESULTS: </b>A marginally non-significant protective association between BCG and leprosy was observed (OR = 0.65, 95% CI 0.40-1.04). The overall vaccine effectiveness (VE) was 35%. The BCG effectiveness was lower for pauci-bacillary leprosy as compared to multibacillary leprosy. The sub-group analysis revealed that the BCG effectiveness was statistically non-significant in less than or equal to 14 years of age and females category. The overall prevented fraction of leprosy was calculated to be 20% (95% CI--1.8-41.4).</p><p><b>CONCLUSION: </b>The current study identified a marginally beneficial role of BCG vaccination in the prevention of leprosy in study population.</p>  a0019-557X